Fresh analysis indicates that people who stop using popular slimming jabs like Mounjaro or Wegovy tend to recover lost weight at a significantly accelerated pace than those who halt conventional lifestyle regimens.
Published data in a leading medical journal demonstrates that while overweight people can lose about a fifth of their body weight while on the medication, the weight comes back at an average rate of 0.8 kg per month once they quit.
"Users purchasing such medications need to be aware of the risk of fast rebound weight gain when the therapy ends," stated researcher Dr. Susan Jebb.
Such speed of recovery suggests a return to original mass within about one and a half years.
Weighing Approaches
The study, which looked at 37 of studies involving over 9,000 of participants, contrasted the outcomes of these new drugs with conventional dieting.
The team emphasize that individuals who lose weight through dieting typically see a more gradual creep back—around 0.1 kg a month—post-intervention.
Understanding the Quick Rebound
Experts believe the mode of action of the injections is key to understanding the heightened weight return.
The injections imitate a natural hormone called glucagon-like peptide-1, which controls hunger.
"Sustained high doses of GLP-1 levels far above than normal could lead to the body to generate a reduced amount of its endogenous hormone, and could lessen responsiveness to its actions," said Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this medication leads to appetite is uncontrolled, making excessive eating much more probable."
A Chronic Condition?
Medical guidelines recommend the jabs for people with obesity-related medical conditions, alongside recommended lifestyle changes.
Professionals argue that, given the significant potential of relapse, the treatment is often long-term.
This view is echoed by pharmaceutical companies, who say that the findings "underscore the persistent character of excess weight," comparing it to managing diseases like hypertension.
Patient Experiences
Individuals who have stopped the medication explain a intense return of cravings.
"I experienced a trigger that goes on and I was suddenly starving," said one woman.
This challenge is compounded if users have not adopted sustainable lifestyle or habit modifications during treatment.
Widespread Interest
Figures show that a significant number of people in the UK have tried these injections in the past year, with desire being substantial.
- Use is more common among women compared to men.
- The 40s and 50s demographic shows the highest level of interest.
- Many obtain the drugs through private prescriptions rather than the NHS.
Ultimately, researchers emphasize that while these medications are effective tools for weight loss, they are not a standalone solution and lasting health benefits likely depends on integrated lifestyle support.
